Clinical Trials

Clinical trials, also known as clinical studies, test potential treatments in human volunteers to see whether they should be approved for wider use in the general population.  A treatment could include a drug, medical device, or biologic, such as a vaccine, blood product, or gene therapy.  Potential treatments must be studied in laboratory animals first to determine potential toxicity before they can be tried in people. Treatments having acceptable safety profiles and showing the most promise are then moved into clinical trials. (FDA.gov)

Clinical trials offer a unique opportunity to patients and medical professionals.  These trials are a way of testing potential treatments for conditions such as brain tumor.  Clinical trials involve patient participation, so the effectiveness of the tested treatment(s) can be accurately gauged.

If you decide that you are interested in participating in a clinical trial, it is important to review all of the materials relative to the clinical trial, with a caregiver if possible, and with your doctor and to ask your doctor about any questions or concerns you may have.

National Institute of Health
To learn more about clinical trials, visit NIH Clinical Research Trials and You

American Brain Tumor Association
To access TrialConnect, a service of the American Brain Tumor Association that links brain tumor patients with potential clinical trials, visit the ABTA's website on Brain Tumor Clinical Trials.

Clinicaltrials.Gov
A registry of federally and privately supported clinical trials conducted in the United States and around the world.  ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details.

Clinical Trials Available in Connecticut

In Connecticut, Nicholas A. Blondin, MD has provided the list below to the CTBTA of local clinical trial opportunities for brain tumor patients available at his office or through the St. Vincent's Brain Tumor Center.  The CTBTA has contacted other brain tumor centers in Connecticut and will update this list as other clinical trial information becomes available.

Newly Diagnosed Glioblastoma

Study Title: Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma
Study Sponsor: Immunocellular Therapeutics, Ltd.
Study Information: https://www.clinicaltrials.gov/ct2/show/study/NCT02546102
Site: Associated Neurologists of Southern Connecticut, PC
Contact: Dr. Nicholas Blondin, nblondin@anscneuro.com or (203) 333-1133

Study Title: A Study of ABT-414 in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance 1)
Study Sponsor: Abbvie
Study Information: https://www.clinicaltrials.gov/ct2/show/study/NCT02573324
Site: Associated Neurologists of Southern Connecticut, PC
Contact: Dr. Nicholas Blondin, nblondin@anscneuro.com or (203) 333-1133


Recurrent Glioblastoma

Study Title: Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery
Study Sponsor: Alliance for Clinical Trials in Oncology
Study Information: https://www.clinicaltrials.gov/ct2/show/study/NCT01814813
Site: St. Vincent’s Brain Tumor Center
Contact: Dr. Nicholas Blondin, nblondin@anscneuro.com or (203) 333-1133

Study Title:  A Feasibility Study of the Nativis Voyager System in Patients With Recurrent Glioblastoma Multiforme (GBM)
Study Sponsor: Nativis, Inc. 
Study Information: https://clinicaltrials.gov/ct2/show/NCT02296580
Site: Associated Neurologists of Southern Connecticut, PC
Contact: Dr. Nicholas Blondin, nblondin@anscneuro.com or (203) 333-1133

 


Brain Metastasis

Study Title: Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
Study Sponsor: NRG Oncology
Study Information: https://www.clinicaltrials.gov/ct2/show/NCT02360215
Site: St. Vincent’s Brain Tumor Center
Contact: Dr. Nicholas Blondin, nblondin@anscneuro.com or (203) 333-1133

Study Title:  Effect of TTFields (150 kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-10 Brain Metastases Following Radiosurgery (METIS)
Study Sponsor: Novocure Ltd. 
Study Information: https://clinicaltrials.gov/ct2/show/study/NCT02831959
Site: Associated Neurologists of Southern Connecticut, PC
Contact: Dr. Nicholas Blondin, nblondin@anscneuro.com or (203) 333-1133

 

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